Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7 API Anti-HIV

Short Description:

Name: Tenofovir Alafenamide Hemifumarate 

CAS: 1392275-56-7

White to Almost White Crystals or Crystalline Powder

Assay: 98.0%~102.0%

A prodrug for Tenofovir, used in combination therapy for the treatment of HIV-1 Infection

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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1392275-56-7 - Description:

1392275-56-7 - Chemical Properties:

Chemical Name Tenofovir Alafenamide Hemifumarate
Synonyms TAF; GS-7340 Hemifumarate
CAS Number 1392275-56-7
Stock Status In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula C25H33N6O9P
Molecular Weight 592.55
Storage Temperature Sealed in Dry, Room Temperature
COA & MSDS Available
Origin of Product    Shanghai, China
Product Categories API (Active Pharmaceutical Ingredient)
Attention For Scientific Research Only and Shall Not be Used for Other Purposes.
Brand Ruifu Chemical

1392275-56-7 - Specifications:

Item Specifications
Appearance White to Almost White Crystals or Crystalline Powder
Solubility  Soluble in Dimethylformamide, and Methanol; Sparingly Soluble in Water and THF; Slightly Soluble in Acetonitrile and Insoluble in Dichloromethane and Toluene
Identification A The IR absorption spectra should be consistent with the reference 
Identification B The retention time of the major peak of the sample solution in the content determination chromatogram conforms to that of the reference solution
Identification C The Fumaric Acid retention time of the major peak in the content determination chromatogram conforms to the peak of the reference
Water Content (by K.F) ≤1.00%
Clarity of Solution Basically no visible particles in 2% (w/v) of the Methanol Solution clarification
Residual Solvent 
Acetonitrile  ≤410ppm
Ethanol ≤5000ppm
Dichloromethane ≤600ppm
Toluene ≤890ppm
Residue on Ignition ≤0.10% 
Heavy Metals ≤20ppm
Related Substances  
PMPA ≤1.00%
PMPA Anhydride ≤0.75%
Single Phenyl PMPA ≤1.00%
Any Unspecified  Impurity ≤0.15%
Total Impurities ≤2.00%
Isomer ≤1.00%
Content of Fumaric Acid 9.0%~13.0% (on the anhydrous basis )
Microbial Limits
Total Aerobic Microbial Count ≤1000CFU/g
Total Yeasts and Molds Count ≤100CFU/g
Escherichia Coli Absent
Assay  98.0%~102.0% (on the anhydrous and solvent-free basis )
Test Standard Enterprise Standard

1392275-56-7 - Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement 

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture 

1392275-56-7 - Advantages:

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1392275-56-7 - FAQ:

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1392275-56-7 - Application:

Tenofovir Alafenamide Hemifumarate (TAF, GS-7340 hemifumarate) (CAS: 1392275-56-7), is a nucleotide reverse transcriptase inhibitor (NRTIs) and a novel prodrug of Tenofovir (TFV). By blocking reverse transcriptase, TAF prevent HIV from multiplying and can reduce the amount of HIV in the body. Tenofovir Alafenamide is a prodrug, which means that it is an inactive drug. In the body, tenofovir alafenamide is converted to Tenofovir diphosphate (TFV-DP). Tenofovir Alafenamide Fumarate was approved in November 2015 for treatment of HIV-1.

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